View source for HCV1a ledipasvir resistance SNP detection

<pre>
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        "name": "HCV1a ledipasvir resistance SNP detection",
        "version": "2.9",
        "review": [
            {
                "status": "approved",
                "reviewer_comment": "Approved by GW staff. Waiting for approval from FDA Reviewer",
                "date": "2017-11-12T12:30:48-0400",
                "reviewer": {
                    "name": "Charles Hadley King",
                    "affiliation": "George Washington University",
                    "email": "hadley_king@gwu.edu",
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                "status": "approved",
                "reviewer_comment": "The revised BCO looks fine",
                "date": "2017-12-12T12:30:48-0400",
                "reviewer": {
                    "name": "Eric Donaldson",
                    "affiliation": "FDA",
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        "created": "2017-01-24T09:40:17-0500",
        "modified": "2018-09-21T14:06:14-0400",
        "contributors": [
            {
                "name": "Charles Hadley King",
                "affiliation": "George Washington University",
                "email": "hadley_king@gwu.edu",
                "contribution": [
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                    "curatedBy"
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            {
                "name": "Eric Donaldson",
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                "email": "Eric.Donaldson@fda.hhs.gov",
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                ]
            }
        ],
        "license": "https://spdx.org/licenses/CC-BY-4.0.html"
    },
    "usability_domain": [
        "Identify baseline single nucleotide polymorphisms (SNPs)[SO:0000694], (insertions)[SO:0000667], and (deletions)[SO:0000045] that correlate with reduced (ledipasvir)[pubchem.compound:67505836] antiviral drug efficacy in (Hepatitis C virus subtype 1)[taxonomy:31646]",
        "Identify treatment emergent amino acid (substitutions)[SO:1000002] that correlate with antiviral drug treatment failure",
        "Determine whether the treatment emergent amino acid (substitutions)[SO:1000002] identified correlate with treatment failure involving other drugs against the same virus",
        "GitHub CWL example: https://github.com/mr-c/hive-cwl-examples/blob/master/workflow/hive-viral-mutation-detection.cwl#L20"
    ],
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    ],
    "description_domain": {
        "keywords": [
            "HCV1a",
            "Ledipasvir",
            "antiviral resistance",
            "SNP",
            "amino acid substitutions"
        ],
        "xref": [
            {
                "namespace": "pubchem.compound",
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                        "name": "Hepatitis C virus genotype 1",
                        "uri": {
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                            "access_time": "2017-01-24T09:40:17-0500"
                        }
                    },
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                            "access_time": "2017-01-24T09:40:17-0500"
                        }
                    },
                    {
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                        "uri": {
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                            "access_time": "2017-01-24T09:40:17-0500"
                        }
                    },
                    {
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                        }
                    },
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                        "access_time": "2017-01-24T09:40:17-0500"
                    }
                ],
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                        "uri": "http://example.com/data/514769/allCount-aligned.csv",
                        "access_time": "2017-01-24T09:40:17-0500"
                    }
                ]
            },
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                "step_number": 2,
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                }
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        "script_driver": "shell",
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                "name": "HIVE-hexagon",
                "version": "babajanian.1",
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                    "access_time": "2017-01-24T09:40:17-0500",
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                }
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                    "access_time": "2017-01-24T09:40:17-0500"
                }
            }
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                "url": "http://example.com/dna.cgi?cmd=login"
            },
            {
                "name": "access to e-utils",
                "url": "http://eutils.ncbi.nlm.nih.gov/entrez/eutils/"
            }
        ],
        "environment_variables": {
            "HOSTTYPE": "x86_64-linux",
            "EDITOR": "vim"
        }
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            "param": "seed",
            "value": "14",
            "step": "1"
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            "param": "minimum_match_len",
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            "step": "1"
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            "param": "divergence_threshold_percent",
            "value": "0.30",
            "step": "1"
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            "param": "freq_cutoff",
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                }
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                    "access_time": "2017-01-24T09:40:17-0500"
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                }
            },
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                    "access_time": "2017-01-24T09:40:17-0500"
                }
            },
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                    "access_time": "2017-01-24T09:40:17-0500"
                }
            }
        ],
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                    "access_time": "2017-01-24T09:40:17-0500"
                }
            },
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                    "access_time": "2017-01-24T09:40:17-0500"
                }
            }
        ]
    },
    "error_domain": {
        "empirical_error": {
            "false_negative_alignment_hits": "<0.0010",
            "false_discovery": "<0.05"
        },
        "algorithmic_error": {
            "false_positive_mutation_calls_discovery": "<0.00005",
            "false_discovery": "0.005"
        }
    }
}
</pre>